Inferential, robust non-negative matrix factorization analysis of microarray data

Inferential, robust non-negative matrix factorization analysis of microarray data

MOTIVATION Modern methods such as microarrays, proteomics and metabolomics often produce datasets where there are many more predictor variables than observations. Research in these areas is often exploratory; even so, there is interest in statistical methods that accurately point to effects that are likely to replicate. Correlations among predictors are used to improve the statistical analysis....

Robust non-negative matrix factorization

Non-negative matrix factorization (NMF) is a recently popularized technique for learning partsbased, linear representations of non-negative data. The traditional NMF is optimized under the Gaussian noise or Poisson noise assumption, and hence not suitable if the data are grossly corrupted. To improve the robustness of NMF, a novel algorithm named robust nonnegative matrix factorization (RNMF) i...

Probabilistic Non-Negative Matrix Factorization: Theory and Application to microarray Data Analysis

Non-negative matrix factorization (NMF) has proven to be a useful decomposition technique for multivariate data, where the non-negativity constraint is necessary to have a meaningful physical interpretation. NMF reduces the dimensionality of non-negative data by decomposing it into two smaller non-negative factors with physical interpretation for class discovery. The NMF algorithm, however, ass...

Non-negative matrix factorization

Non-negative Matrix Factorization via Archetypal Analysis

Given a collection of data points, non-negative matrix factorization (NMF) suggests to express them as convex combinations of a small set of ‘archetypes’ with non-negative entries. This decomposition is unique only if the true archetypes are non-negative and sufficiently sparse (or the weights are sufficiently sparse), a regime that is captured by the separability condition and its generalizati...